Cytochrome P450 and lipoxygenase pathways
Method validated for several of the mono- and di-oxygenated metabolites in plasma and cerebrospinal fluid
Biomarkers:
Hydroxyeicosatetraenoic acid (HETE) metabolites
- 12-HETE
- 15-HETE
- 20-HETE
Epoxyeicosatrienoic acid (EET) metabolites
- 8,9 - EET
- 11,12 - EET
- 14,15 - EET
Dihydroxyeicosatrienoic acid (DiHETrE) metabolites
- 5,6 - DiHETrE
- 8,9 - DiHETrE
- 11,12 - DiHETrE
- 14,15 - DiHETrE
Linoleic acid metabolites
- 9,10 - DiHOME
- 9,10 - EpOME
Typical Limit of Quantitation: 0.2 ng/ml
Typical sample volume: 1.0 ml cerebrospinal fluid (CSF)